Endocrine Abstracts

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Based on current definitions four different phenotypes have been established by Rotterdam criteria. In 2006 the Androgen Excess Society (AES) postulated that PCOS is basicly hyperandrogenic state and the presence of clinical and/or laboratory hyperandrogenism constitutes a sine qua non for PCOS diagnosis. These criteria were further consolidated in 2009 by the AES and PCOS Soci...

Introduction: Vasovagal syncope (VVS) is a transient loss of conscioussness due to hypoperfusion of the brain caused by vasodepressoric and/or cardioinhibitory reflex. In the pathogenesis, a dysregulation of autonomic nervous system is playing an important role. There is a growing evidence about more complex neurohumoral background of VVS. Neuropeptide Y (NPY) is hormone involved in the regulation of blood pressure with potent vasoconstriction effect. Moreover, NPY is also a c...

Bisphenol A (BPA) is an environmental estrogen found in plastic material such as bottles, food package, dental material, etc. It is known to have many negative effects on human health and its exposure is associated with endocrine disorders including polycystic ovary syndrome (PCOS). Some studies found significantly higher serum and urinary levels of BPA in PCOS women, however its association with steroid hormones is still controversial.Aim: The aim of th...

Objective: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder characterised by menstrual dysfunction, infertility, presence of polycystic ovaries and biochemical and clinical hyperandrogenism affecting up to 4–18% women of reproductive age. Vitamin D is thought to influence the development of PCOS through gene transcription and hormonal modulation of insulin metabolism and fertility regulation. The aim of this prospective case–control study was to...

This multi centre observational cohort study gives a view about the occurrence, clinical and laboratory presentation, localization, histological type and genetic background of pheochromocytoma (PHEO) and paraganglioma (PGL) in Eastern Slovakia. It included 28 patients (18 women +10 men), of which 23 were diagnosed to have PHEO (82.1%) and seven patients (25%) suffered from PGL with retroperitoneal, inguinal/pelvic and mediastinal distribution. Arterial hypertension was the maj...

Autoimmune thyroid diseases (AITD), such as Hashimoto’s thyroiditis (HT) and Grave’s disease (GD) frequently form overlap syndromes with rheumatoid arthritis (RA). Among genetic factors, the role of the HLA antigens and CTLA4 gene polymorphisms in the formation of such overlap syndromes has been suggested.Objective: Aim of this study was to investigate the alleli and genotypes frequency of the CTLA4 exon1 A49G polymorphism in Slovak patients wi...

The aim of the present study was to evaluate and compare the response of 17 OHP to ACTH stimulation in patients with various types of adrenal incidentalomas and to examine the occurence of germline CYP21 mutation in these patients.Subjects and methods: Forty patients (27 females, 13 males) with unilateral and bilateral masses were screened for five most common mutations of the CYP21 in peripheral blood DNA samples. A hormonal evaluation, i.e. baseline pl...

It is well known that adrenal masses, particularly adenomas are frequently related to metabolic syndrome and insulin resistance. However, there are no reported data about the differences between adenomas and hyperplasia.Authors examined the prevalence of symptoms of the metabolic syndrome and insulin resistance in 25 patients with adrenal incidentalomas (10 men, 15 women) of the mean age 57.9+15 years. 15 patients had adrenal adenoma determined by CT or ...

Objectives: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women. Its increasing prevalence is probably related to environmental estrogens exposure, such as bisphenol A (BPA). BPA is considered to play an important role in the ethiopathogenesis of PCOS and can be responsible for various clinical symptoms. Aim of the study was to compare the levels of urinary BPA between PCOS women and healthy controls and to assess the relationship of BPA to sex...

Background: There is evidence that polycystic ovary syndrome (PCOS) is commonly associated with higher cardiometabolic risk. Aim of the study was to compare various sex streoids in PCOS women with overweight or obesity (BMI >27) and those with lower BMI. Second aim of the study was to determine the relationship of various sexual setroids to cardiovascular risk in PCOS women.Subjects and methods: Study included 64 Caucasian women with PCOS. F...